Running Hand2Note4 together with many Google Chrome tabs dramatically slows down your PC. Limit Chrome to 2 tabs during play, or switch to a different browser for sessions.
Lower the number of max threads used in the program settings:
4 threads if you are using Google Chrome
8 threads if you are not
(Recommendation for 32 GB RAM)
After changing this setting, make sure to rebuild your stats.

Remove unnecessary stats via Configuration > Delete Unused Stats (make sure to archive your
Config folder beforehand). After doing this, you will need to rebuild your stats.

To minimize the database size and improve performance:
The database rebuild process works as follows: stats are calculated in RAM and only then written to the disk.